THE FULL
SCENE

IN THE CRIME OF SEVERE
ASTHMA INFLAMMATION

 

The Inflammatory Cascade

TSLP is a key epithelial cytokine that sits at the top of the inflammatory cascade and offers a new way to think about severe asthma.1-3

For people with severe asthma, the epithelium is often the starting point for an overactive immune response as it is the first point of contact for viruses, allergens and other various insults shown below. Epithelial cytokines, like TSLP, respond to these insults by initiating immune responses via multiple downstream effector cells.1-3

Test Your Knowledge

Drag and drop the immune cells into the inflammatory cascade.

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eleven
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Airway Smooth Muscle Cells
B Cell
Dendritic Cell
Dendritic Cell
Eosinophil
ILC2
Leukotrienes
Mast Cell
Neutrophil
Th17
Th2
Th0
Th0
TSLP
 

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Quiz
Quiz

Can You Outsmart TSLP?

Answer the following questions to see how much you know about the role of TSLP in severe asthma inflammation.

Take a Closer Look

Watch the Mechanism of Disease video to get an in-depth look at TSLP and the rest of the inflammatory cascade.

Take a Closer Look

Watch the Mechanism of Disease video to get an in-depth look at TSLP and the rest of the inflammatory cascade.

See Who’s Involved

Neutrophil Frame

Neutrophil Cell

Eosinophil Frame

Eosinophil

B Cell Frame

B Cell

TSLP Frame

TSLP

Find out why the main suspects—Eosinophil, IgE-producing B cell, and Neutrophil—call TSLP a real mastermind in the crime of severe asthma inflammation.1-3,9

Are you a healthcare professional and still have questions about TSLP?

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References: 1. Corren J. J Allergy Clin Immunol Pract. 2019;7(5):1394-1403. 2. Lambrecht BN, Hammad H, Fahy JV. Immunity. 2019;50(4):975-991. 3. Lambrecht BN, Hammad H. Nat Immunol. 2015;16(1):45-56. 4. Brusselle G, Bracke K. Ann Am Thorac Soc. 2014;11:S322-S328. 5. Pelaia G, et al. Nat Rev Drug Discov. 2012;11:958-997. 6. Pasha MA, et al. Allergy Asthma Proc. 2019;40(3):138-145. 7. Brusselle G, et al. Nat Med. 2013;19:977-979. 8. Gauvreau GM et al. Expert Opinion on Therapeutic Targets. 2020; 24:8, 777-792. 9. Liang Y, Yu B, Chen J, et al. J Allergy Clin Immunol. 2019;144(4):1025-1035. 10. Li Y, Wang W, Lv Z, et al. J Immunol. 2018;200(7):2253-2262. 11. Tanaka J, Watanabe N, Kido M, et al. Clin Exp Allergy. 2009;39(1):89-100. 12. Chesné J, Braza F, Mahay G, et al. Am J Respir Crit Care Med. 2014;190(10):1094-1101. 13. Ying S, O'Connor B, Ratoff J, et al. J Immunol. 2005;174(12):8183-8190. 14. Ziegler SF, Artis D. Nat Immunol. 2010;11(4):289-293.