Suspect Severe Asthma Inflammation
Suspect Severe Asthma Inflammation

IgE, immunoglobulin E; TSLP, thymic stromal lymphopoietin.

In the crime of severe asthma inflammation…

Made Us Do It

IgE, immunoglobulin E; TSLP, thymic stromal lymphopoietin.

TSLP is a key epithelial cytokine that sits at the top of the inflammatory cascade and offers a new way to think about severe asthma.1-3

For some people with severe asthma, the epithelium is the starting point for an overactive immune response to various insults such as1-3:

This overexpression of TSLP can result in pathologic inflammation, which can cause increased symptoms and asthma exacerbations.1-3,8

Watch the Mechanism of Disease Video

to learn more about the role of TSLP in severe asthma.


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References: 1. Corren J. J Allergy Clin Immunol Pract. 2019;7(5):1394-1403. 2. Lambrecht BN, Hammad H, Fahy JV. Immunity. 2019;50(4):975-991. 3. Lambrecht BN, Hammad H. Nat Immunol. 2015;16(1):45-56. 4. Liang Y, Yu B, Chen J, et al. J Allergy Clin Immunol. 2019;144(4):1025-1035. 5. Li Y, Wang W, Lv Z, et al. J Immunol. 2018;200(7):2253-2262. 6. Tanaka J, Watanabe N, Kido M, et al. Clin Exp Allergy. 2009;39:89-100. 7. Chesné J, Braza F, Mahay G, et al. Am J Respir Crit Care Med. 2014;190(10):1094-1101. 8. Ying S, O'Connor B, Ratoff J, et al. J Immunol. 2005;174(12):8183-8190.