In the crime of severe asthma inflammation…

“TSLP MADE
US DO IT”

Suspect Severe Asthma Inflammation
Suspect Severe Asthma Inflammation
 
Real Mastermind in the Crime of Severe Asthma Inflammation

A Real Mastermind

It’s been revealed that thymic stromal lymphopoietin (TSLP), a key epithelial cytokine at the top of the inflammatory cascade, has been giving orders to multiple downstream effector cells, like Eosinophil, IgE-producing B cell, and Neutrophil.1,2 This can lead to pathologic inflammation, which can cause increased symptoms and asthma exacerbations.1,3-5

The Scene of the Crime

The airway epithelium is a common source of inflammation and a central factor in asthma pathology.3,4 It is a protective barrier, a mediator of immunity, and potential starting point for airway remodeling.3,4,6-8

It is the first point of contact for viruses, allergens, pollutants, bacteria, physical injury, and other external insults. TSLP is released by the epithelium in response to these insults.1,3,4

 
Epithelium, a Common Source of Inflammation
Inflammatory Cascade
Inflammatory Cascade

There’s more to see! Tour the inflammatory cascade from the airway epithelium down to the airway smooth muscle cells to see how TSLP can play a key role in allergic inflammation, eosinophilic inflammation, and potentially neutrophilic inflammation.1,3,4,14-17

See Who’s Involved

Neutrophil Frame

Neutrophil Cell

Eosinophil Frame

Eosinophil

B Cell Frame

B Cell

TSLP Frame

TSLP

Find out why the main suspects—Eosinophil, IgE-producing B cell, and Neutrophil—call TSLP a real mastermind in the crime of severe asthma inflammation.1-4

Scan the Evidence

Watch the Mechanism of Disease Video

Explore Additional Resources

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VIDEO ARCHIVES

Watch the Virtual TSLP Speaker Programs to learn more about TSLP and severe asthma inflammation from our experts.

 

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PRESENTATIONS

Download Virtual TSLP Speaker Program materials to learn more about TSLP and severe asthma inflammation from our experts.

 

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ADDITIONAL DOCUMENTATION

View and download additional information on TSLP and severe asthma inflammation.

Virtual Investigation Experience

Explore the TSLP Investigation Hub to hear more from the main suspects and find out additional information on the crime of severe asthma inflammation.

Virtual TSLP Speaker Programs

May 26 8 PM EDT

TSLP in Asthma: Examining the Evidence

Hosted by Dr. Sameer Mathur, MD - Allergist, University of Wisconsin Severe Asthma Clinic, Madison, WI

 

Learn more about TSLP and the role it can play in the crime of severe asthma inflammation.

Are you a healthcare professional and still have questions about TSLP?

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References: 1. Corren J. J Allergy Clin Immunol Pract. 2019;7(5):1394-1403. 2. Ziegler SF, Artis D. Nat Immunol. 2010;11(4):289-293. 3. Lambrecht BN, Hammad H, Fahy JV. Immunity. 2019;50(4):975-991. 4. Lambrecht BN, Hammad H. Nat Immunol. 2015;16(1):45-56.5. Ying S, O'Connor B, Ratoff J, et al. J Immunol. 2005;174(12):8183-8190. 6. Bartemes KR, Kita H. Clin Immunol. 2012;(3):222-235. 7. Redhu NS, Gounni AS. Clin Exp Allergy. 2012;42(7):994-1005. 8. Roan F, et al. J Clin Invest. 2019;12(4):1441-1451. 9. Brusselle G, Bracke K. Ann Am Thorac Soc. 2014;11:S322-S328. 10. Pelaia G, et al. Nat Rev Drug Discov. 2012;11:958-997. 11. Pasha MA, et al. Allergy Asthma Proc. 2019;40(3):138-145. 12. Brusselle G, et al. Nat Med. 2013;19:977-979. 13. Gauvreau GM et al. Expert Opinion on Therapeutic Targets. 2020; 24:8, 777-792. 14. Liang Y, Yu B, Chen J, et al. J Allergy Clin Immunol. 2019;144(4):1025-1035. 15. Li Y, Wang W, Lv Z, et al. J Immunol. 2018;200(7):2253-2262. 16. Tanaka J, Watanabe N, Kido M, et al. Clin Exp Allergy. 2009;39(1):89-100. 17. Chesné J, Braza F, Mahay G, et al. Am J Respir Crit Care Med. 2014;190(10):1094-1101.

 

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